Module Handbook

  • Dynamischer Default-Fachbereich geändert auf MV

Notes on the module handbook of the department Mechanical and Process Engineering

Die hier dargestellten veröffentlichten Studiengang-, Modul- und Kursdaten des Fachbereichs Maschinenbau und Verfahrenstechnik ersetzen die Modulbeschreibungen im KIS und wuden mit Ausnahme folgender Studiengänge am 28.10.2020, bzw. am 13.01.2021 verabschiedet.


Module MV-BioVT-M103-M-7

Bioprocess Engineering II (M, 9.0 LP)

Module Identification

Module Number Module Name CP (Effort)
MV-BioVT-M103-M-7 Bioprocess Engineering II 9.0 CP (270 h)


CP, Effort 9.0 CP = 270 h
Position of the semester 1 Sem. in WiSe
Level [7] Master (Advanced)
Language [DE/EN] German or English as required
Module Manager
Area of study [MV-BioVT] Bioprocess Engineering
Reference course of study [MV-88.805-SG] M.Sc. Biological Process Engineering
Livecycle-State [NORM] Active


Type/SWS Course Number Title Choice in
Presence-Time /
SL SL is
required for exa.
PL CP Sem.
2V MV-BioVT-86434-K-7
P 28 h 62 h - - PL1 3.0 WiSe
1V+1U MV-BioVT-86433-K-7
Downstream Processing in Biotechnology II
P 28 h 62 h - - PL2 3.0 WiSe
3L MV-BioVT-86441-K-7
Bioprocess Engineering Lab II
P 42 h 48 h - - PL3 3.0 WiSe
  • About [MV-BioVT-86434-K-7]: Title: "Biorefinement"; Presence-Time: 28 h; Self-Study: 62 h
  • About [MV-BioVT-86433-K-7]: Title: "Downstream Processing in Biotechnology II"; Presence-Time: 28 h; Self-Study: 62 h
  • About [MV-BioVT-86441-K-7]: Title: "Bioprocess Engineering Lab II"; Presence-Time: 42 h; Self-Study: 48 h

Examination achievement PL1

  • Form of examination: talk (20-30 Min.)
  • Examination Frequency: each semester
  • Examination number: 10434 ("Biorefinement")

Examination achievement PL2

  • Form of examination: oral examination (30 Min.)
  • Examination Frequency: each semester
  • Examination number: 10433 ("Downstream Processing in Biotechnology II")

Examination achievement PL3

  • Form of examination: practical laboratory exam
  • Examination Frequency: Examination only within the course
  • Examination number: 10441 ("Bioprocess Engineering Lab II")

Evaluation of grades

All partial module examinations have to be passed. The module grade is the arithmetic mean of all partial examination grades.


The lecture focuses on the sustainable use of renewable resources by biotechnological or chemical means (integrated biorefinery concepts). The following topics will be treated in detail:
  • Overview of biorefinery concepts
  • Concept of the Biobased Economy
  • Coupling of the biorefinery to chemical production networks
  • Sugar- and starch-based biorefineries
  • Whole plant biorefinery
  • Lignocellulose Biorefinery
  • Enzymes for biorefineries
  • Biorefinery product families (sugar, lignin, biopolymers, specialty chemicals)
  • Repeated introduction to the topic of downstream processing of bioprocesses (cell harvesting, digestion, coarse and fine purification of products)
  • Affinity processes in the purification (e.g. membrane adsorbers, TAGs)
  • Magnetic separation processes
  • Electrical separation processes (e.g. electrophoresis, electrodialysis)
  • Solvent extraction in bioprocess technology
  • Isolation of cells (e.g. cytometry, isolation of stem cells)

The procedures are explained using practical examples. The focus is on microbial processes as well as the processing of fermentations of animal and plant cells.

  • Cultivation of a GMO for heterologous expression of a cytochrome P450 monooxygenase
  • Induction of the expression of the target enzyme
  • Purification of monooxygenase using various affinity techniques
  • Characterization of the purified enzyme
  • Basic balancing of the process
  • Simulation and scaling of the process

Competencies / intended learning achievements

The students are able to
  • develop different biorefinery concepts
  • make economic and ecological assessments of biorefineries
  • reflect existing industrial biorefinery concepts
  • understand and evaluate complex industrial concepts for the use of renewable resources
  • independently calculate material and energy flows in industrial systems using SuperProDesigner
The students are able to
  • to reproduce advanced chromatography
  • to explain affinity processes (e.g. membrane adsorbers) and electrical separation processes (e.g. electrophoresis, electrodialysis)
  • to calculate magnetic separation processes
  • to explain drying and crystallization processes
  • to independently develop and dimension a purification process for a given bioprocess
The students are able
  • to explain basic principles of heterologous expression of proteins, biotechnological processes independently,
  • to apply affinity techniques for the purification of recombinant proteins,
  • to perform process simulation
  • to present and discuss their results in the laboratory group
  • to present their results in the form of an experimental protocol and discuss them in detail


  • B. Kamm, P.R. Gruber, M. Kamm; Biorefineries – Industrial Processes and Products; Wiley-VCH ISBN-10: 3-527-31027-4

Current literature will be provided in the lecture.

Current literature will be made available in the lecture.
  • Script for the internship
  • W. Storhas; Bioverfahrensentwicklung; Wiley-VCH (2003) ISBN 3-527-28866-X
  • H. Chmiel; Bioprozesstechnik; Elsevier ISBN 3-8247-1607-8

Requirements for attendance of the module (informal)

In-depth knowledge of bioprocess technology (e.g. through corresponding BSc. degree), basic chemical and microbiological knowledge


Requirements for attendance of the module (formal)


References to Module / Module Number [MV-BioVT-M103-M-7]

Course of Study Section Choice/Obligation
[MV-88.805-SG] M.Sc. Biological Process Engineering [Compulsory Modules] Pflichtmodule [P] Compulsory
Module-Pool Name
[MV-ALLG-2022-MPOOL-6] Wahlpflichtmodule Master allgemein 2022
[MV-ALL-MPOOL-6] Wahlpflichtmodule allgemein