Module Handbook

  • Dynamischer Default-Fachbereich geändert auf MV

Notes on the module handbook of the department Mechanical and Process Engineering

Die hier dargestellten veröffentlichten Studiengang-, Modul- und Kursdaten des Fachbereichs Maschinenbau und Verfahrenstechnik ersetzen die Modulbeschreibungen im KIS und wuden mit Ausnahme folgender Studiengänge am 28.10.2020, bzw. am 13.01.2021 verabschiedet.

Ausnahmen:

Module MV-BioVT-M102-M-4

Bioprocess Engineering I (M, 8.0 LP)

Module Identification

Module Number Module Name CP (Effort)
MV-BioVT-M102-M-4 Bioprocess Engineering I 8.0 CP (240 h)

Basedata

CP, Effort 8.0 CP = 240 h
Position of the semester 2 Sem. from WiSe/SuSe
Level [4] Bachelor (Specialization)
Language [DE/EN] German or English as required
Module Manager
Lecturers
Area of study [MV-BioVT] Bioprocess Engineering
Reference course of study [MV-88.805-SG] M.Sc. Biological Process Engineering
Livecycle-State [NORM] Active

Courses

Type/SWS Course Number Title Choice in
Module-Part
Presence-Time /
Self-Study
SL SL is
required for exa.
PL CP Sem.
2V MV-BioVT-86437-K-4
Biotransformation and Biocatalysis
P 28 h 62 h - - PL1 3.0 WiSe
2V+1U MV-BioVT-86432-K-7
Bioprocess Engineering II
P 42 h 108 h - - PL2 5.0 SuSe
  • About [MV-BioVT-86437-K-4]: Title: "Biotransformation and Biocatalysis"; Presence-Time: 28 h; Self-Study: 62 h
  • About [MV-BioVT-86432-K-7]: Title: "Bioprocess Engineering II"; Presence-Time: 42 h; Self-Study: 108 h

Examination achievement PL1

  • Form of examination: written or oral examination
  • Examination Frequency: each semester
  • Examination number: 10437 ("Biotransformation and Biotechnology")
    written (120 minutes) or oral (30 minutes) examination

Examination achievement PL2

  • Form of examination: oral examination (30 Min.)
  • Examination Frequency: each semester
  • Examination number: 10432 ("Bioprocess Engineering II")

Evaluation of grades

All partial module examinations have to be passed. The module grade is the weighted average of the partial examination grades according to the following weights:

Biotransformation and Biocatalysis 3/8, Bioprocess Engineering II 5/8

Contents

  • Introduction (Definition of Biocatalysis/Biotransformation; History of Biocatalysis)
  • Biosynthesis, structure and mode of action of enzymes
  • Extraction and production of enzymes
  • Nomenclature and enzyme classes
  • Immobilization of enzymes
  • Kinetics of enzymatic reactions
  • Regulation & inhibition of enzymatic reactions
  • Optimization of enzymes
  • Reactors for Biocatalysis & Biotransformation
  • General applications; Co-substrate recycling
  • Industrial applications of oxidoreductases
  • Industrial applications of transferases
  • Industrial applications of hydrolases
  • Industrial applications of lyases
  • Industrial applications of isomerases
  • Industrial applications of ligases
  • Whole cell biotransformations
The module is divided into two equally weighted blocks. In the first block special procedures of bioprocess technology are discussed:
  • Cultivation of plant cells (auxotrophic and phototrophic)
  • Animal cell cultures
  • Insect cells
  • Marine Biotechnology
  • Single-Use Systems
  • Industrial Biocatalysis

In the second block, the following topics are covered:

  • Principles of bioprocess modelling
  • Introduction to Berkeley Madonna
  • Examples of dynamic bioprocess simulation
  • Evaluation of bioprocesses under the aspect of sustainability
  • Introduction to SuperProDesigner
  • Case studies

Competencies / intended learning achievements

The students are able
  • to describe the use of isolated enzymes and whole cell systems in technical systems
  • to explain the structure and function of enzymes
  • to calculate kinetic quantities of enzymatic reactions
  • to analyze enzymatic inhibitions
  • to independently design and calculate biocatalytic processes
  • to explain immobilization procedures
  • to present and to advise on the development of a biocatalytic process
1. Lecture

The students are able

  • to realize technical bioprocesses with different cell systems
  • to evaluate the use of animal cell cultures in human protein production
  • to explain differences between prokaryotic and eukaryotic production systems
  • to combine biological system parameters with process engineering parameters and to calculate processes independently
  • to name process strategies using phototrophic organisms.
  • to explain and analyze complex biotechnological processes

2. Exercise

The students are able

  • to model and simulate bioprocesses with appropriate software tools
  • to analyze and independently set up complex modeling and simulation of bioprocesses
  • to present and discuss their results in the exercise group
  • to assign kinetic parameters to different bioprocesses

Literature

Will be announced during the event.
  • I.J. Dunn, E. Heinzle, J. Ingham, J.E. Prenosil; Biological Reaction Engineering; Wiley-VCH ISBN 3-527-29776-6
  • E. Heinzle, A. Biwer, C. Cooney; Development of Sustainable Bioprocesses; Wiley ISBN-10 0-470-01559-4

Requirements for attendance of the module (informal)

In-depth knowledge of bioprocess technology (e.g. through corresponding B.Sc. degree)

Requirements for attendance of the module (formal)

None

References to Module / Module Number [MV-BioVT-M102-M-4]

Course of Study Section Choice/Obligation
[MV-88.805-SG] M.Sc. Biological Process Engineering [Compulsory Modules] Pflichtmodule [P] Compulsory
Module-Pool Name
[MV-ALLG-2022-MPOOL-6] Wahlpflichtmodule Master allgemein 2022
[MV-ALL-MPOOL-6] Wahlpflichtmodule allgemein
[MV-EVT-2022-MPOOL-4] Wahlpflichtmodule B.Sc. EVT 2022